Prednisone (Prednisolone)

Prednisone Side Effects

Patients taking long-term Prednisone often receive supplements of calcium and vitamin D to counteract the side effects on bones. Calcium and vitamin D probably are not enough, however, and treatment with bisphosphonates such as alendronate (Fosamax) and risedronate (Actonel) may be necessary. The development of osteoporosis and the need for treatment can be monitored, using bone density scans.

Prednisone side effects and side effects of other corticosteroids range from mild annoyances to serious, irreversible damage, and they occur more frequently with higher doses and more prolonged treatment.

Prednisone may cause puffiness of the face (so-called moon face), growth of facial hair, thinning and easy bruising of the skin, impaired wound-healing, glaucoma, cataracts, ulcers in the stomach and duodenum, worsening of diabetes, irregular menses, rounding of the upper back ("buffalo hump"), obesity, retardation of growth in children, convulsions, and psychiatric disturbances.

Prednisone side effects include retention of sodium (salt) and fluid, weight gain, high blood pressure, headache, loss of potassium and muscle weakness.

The psychiatric disturbances include depression, euphoria, insomnia, mood swings, personality changes, and even psychotic behavior. Prednisone suppresses the immune system and, therefore, increases the frequency or severity of infections and decreases the effectiveness of vaccines and antibiotics. Prednisone may cause osteoporosis that results in fractures of bones.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.